Human memory B cells: Memory B cells of a special kind
نویسندگان
چکیده
منابع مشابه
Human IgM+CD27+ B cells: memory B cells or "memory" B cells?
Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27-) B cells following stimulation in vitro, consistent with the heightened kinetics of secondary responses in vivo. CD27+ B cells expres...
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More than half of the nascent B cells in humans initially express autoreactive antibodies. However, most of these autoantibodies are removed from the repertoire at two checkpoints before maturation into naive B cells. A third checkpoint excludes remaining autoantibodies from the antigen-experienced IgM(+) memory B cell pool. Nevertheless, low-affinity self-reactive antibodies are frequently fou...
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The human peripheral B cell compartment displays a large population of IgM IgD CD27 memory B cell carrying a mutated Ig + + + “ ” receptor. We show here, by phenotypic analysis, CDR3 spectratyping during a T-independent response and gene expression profiling of the different blood and splenic B cell subsets, that blood IgM IgD CD27 cells correspond to circulating splenic marginal zone B cells. ...
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Class-switched memory B cells are key components of the "reactive" humoral immunity, which ensures a fast and massive secretion of high-affinity antigen-specific antibodies upon antigenic challenge. In humans, IgA class-switched (IgA+ ) memory B cells and IgA antibodies are abundant in the blood. Although circulating IgA+ memory B cells and their corresponding secreted immunoglobulins likely po...
متن کاملSilent development of memory progenitor B cells.
T cell-dependent immune responses generate long-lived plasma cells and memory B cells, both of which express hypermutated Ab genes. The relationship between these cell types is not entirely understood. Both appear to emanate from the germinal center reaction, but it is unclear whether memory cells evolve while obligatorily generating plasma cells by siblings under all circumstances. In the expe...
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ژورنال
عنوان ژورنال: Immunology & Cell Biology
سال: 2008
ISSN: 0818-9641,1440-1711
DOI: 10.1038/icb.2008.59